Brian O'Brien may refer to:Brian O'Brien (1898–1992), American optical physicist and the founder of the Air Force Studies Board Brian O'Brien (1934–2020), Australian physicist and space scientist Brian O'Brien (1939–2023), Irish rugby union player and coach Brian O'Brien (journalist) (1922–1982), New Zealand sports journalist and politician Clock (character), a fictional crime-fighter whose alter ego is Brian O'Brien

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