General Hospital is the longest running American television serial drama, airing on ABC. Created by Frank and Doris Hursley, who originally set it in a general hospital, in an unnamed fictional city. In the 1970s, the city was named Port Charles, New York. The series premiered on April 1, 1963. This is a list of notable characters who significantly impacted storylines and began their run, or significantly returned, from the years 1963 to 1969.

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